Merck 100631.1000 Salicylic acid

Ürün Özellikleri

CAS #	EC Number	Hill Formula	Chemical Formula	Molar Mass	Grade Value
69-72-7	200-712-3	C₇H₆O₃	HOC₆H₄COOH	138.12 g/mol	Ph Eur,BP,USP

Description
Catalogue Number	100631
Synonyms	2-Hydroxybenzoic acid
Description	Salicylic acid

Product Information
CAS number	69-72-7
EC number	200-712-3
Grade	Ph Eur,BP,USP
Hill Formula	C₇H₆O₃
Chemical formula	HOC₆H₄COOH
Molar Mass	138.12 g/mol
HS Code	2918 21 00
Structure formula Image

Applications
Application	Salicylic acid suitable for use as excipient EMPROVE® exp Ph Eur,BP,USP. CAS 69-72-7, EC Number 200-712-3, chemical formula HOC₆H₄COOH. Salicylic acid MSDS (material safety data sheet) or SDS, storage and handling info here. Synonyms: 2-Hydroxybenzoic acid

Physicochemical Information
Boiling point	211 °C (1013 hPa)
Density	1.443 g/cm3 (20 °C)
Flash point	157 °C
Ignition temperature	500 °C
Melting Point	157 – 159 °C
pH value	2.4 (H₂O) (saturated solution)
Vapor pressure	<1 hPa (100 °C)
Bulk density	400 – 500 kg/m3
Solubility	2 g/l

Toxicological Information
LD 50 oral	LD50 Rat 1250 – 1580 mg/kg
LD 50 dermal	LD50 Rat > 2000 mg/kg

Safety Information according to GHS
Hazard Pictogram(s)
Hazard Statement(s)	H302: Harmful if swallowed. H318: Causes serious eye damage.
Precautionary Statement(s)	P280: Wear eye protection. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P313: Get medical advice/ attention.
RTECS	VO0525000

Safety Information
R Phrase	R 22-41 Harmful if swallowed.Risk of serious damage to eyes.
S Phrase	S 22-24-26-39 Do not breathe dust.Avoid contact with skin.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear eye/face protection.

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Specifications
Assay (acidimetric; calculated on dried substance)	99.5 – 100.5 %
Assay (HPLC, calc.on dried substance)	98.0 – 102.0 %
Identity	passes test
Appearance of solution (10 %; ethanol 96 %)	passes test
Chloride (Cl)	≤ 0.0100 %
Sulphate (SO₄)	≤ 0.0200 %
Heavy metals (as Pb)	≤ 0.0020 %
Related substances / HPLC (EP) (4-Hydroxybenzoic acid)	≤ 0.1 %
Related substances / HPLC (EP) (4-Hydroxyisophthalic acid)	≤ 0.05 %
Related substances / HPLC (EP) (Phenol)	≤ 0.02 %
Related substances / HPLC (EP) (Largest unspecified impurity)	≤ 0.05 %
Related substances / HPLC (EP) (Sum of all impurities)	≤ 0.2 %
Related substances / HPLC (USP) (4-Hydroxybenzoic acid)	≤ 0.1 %
Related substances / HPLC (USP) (4-Hydroxyisophthalic acid)	≤ 0.05 %
Related substances / HPLC (USP) (Phenol)	≤ 0.02 %
Related substances / HPLC (USP) (Largest unspecified impurity)	≤ 0.05 %
Related substances / HPLC (USP) (Sum of all impurities)	≤ 0.2 %
Residual solvents (ICH Q3C)	passes test
Sulfated ash	≤ 0.05 %
Loss on drying	≤ 0.5 %
Residues of metal catalysts or metal reagents acc. to EMEA/CHMP/SWP/4446/2000 are not likely to be present. corresponds to Ph Eur, BP, USP

Salicylic acid suitable for use as excipient EMPROVE® exp Ph Eur,BP,USP. CAS 69-72-7, EC Number 200-712-3, chemical formula HOC₆H₄COOH. Salicylic acid MSDS (material safety data sheet) or SDS, storage 1.00631.1000

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