Merck 100995.2500 2-Propanol suitable

for use as excipient EMPROVE® exp Ph Eur,BP,JP,USP

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2-Propanol suitable for use as excipient EMPROVE® exp Ph Eur,BP,USP

CAS # EC Number Hill Formula Chemical Formula Molar Mass Grade Value
67-63-0 200-661-7 C₃H₈O CH₃CH(OH)CH₃ 60.1 g/mol Ph Eur,BP,JP,USP
Description
Catalogue Number 100995
Synonyms Isopropyl alcohol, Isopropanol, iso-Propanol, IPA

Product Information
CAS number 67-63-0
EC index number 603-117-00-0
EC number 200-661-7
Grade Ph Eur,BP,JP,USP
Hill Formula C₃H₈O
Chemical formula CH₃CH(OH)CH₃
Molar Mass 60.1 g/mol
HS Code 2905 12 00
Structure formula Image

Applications
Application 2-Propanol suitable for use as excipient EMPROVE® exp Ph Eur,BP,JP,USP. 2-Propanol CAS No. 67-63-0, EC Number 200-661-7. 2-Propanol MSDS (material safety data sheet) or SDS here.

Physicochemical Information
Boiling point 82.4 °C (1013 hPa)
Density 0.786 g/cm3 (20 °C)
Evaporation number 11
Explosion limit 2 – 13.4 %(V)
Flash point 12 °C
Ignition temperature 425 °C
Melting Point -89.5 °C
Vapor pressure 43 hPa (20 °C)
Refractive Index 1.378

Toxicological Information
LD 50 oral LD50 Rat 5045 mg/kg
LD 50 dermal LD50 Rabbit 12800 mg/kg

Safety Information according to GHS
Hazard Pictogram(s)

Hazard Statement(s) H225: Highly flammable liquid and vapour.
H319: Causes serious eye irritation.
H336: May cause drowsiness or dizziness.
Precautionary Statement(s) P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P240: Ground/bond container and receiving equipment.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
RTECS NT8050000

Safety Information
R Phrase R 11-36-67
Highly flammable.Irritating to eyes.Vapours may cause drowsiness and dizziness.
S Phrase S 7-16-24/25-26
Keep container tightly closed.Keep away from sources of ignition – No smoking.Avoid contact with skin and eyes.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Transport Information
Declaration (railroad and road) ADR, RID UN 1219 , 3, II
Declaration (transport by air) IATA-DGR UN 1219 , 3, II
Declaration (transport by sea) IMDG-Code UN 1219 , 3, II

Specifications
Assay (GC) ≥ 99.5 %
Identity (IR) conforms
Identity B (USP) conforms
Identity (JP) conforms
Appearance conforms
Clarity of solution conforms
Acidity or alkalinity conforms
Acidity conforms
Refractive index (n 20/D) 1.376 – 1.378
Density (d 20 °C/20 °C) 0.785 – 0.788
Density (d 25 °C/25 °C) 0.783 – 0.787
Boiling range (81-83°C) ≥ 94 % (v/v)
Absorbance (at 230 nm) ≤ 0.300
Absorbance (at 250 nm) ≤ 0.100
Absorbance (at 270 nm) ≤ 0.030
Absorbance (at 290 nm) ≤ 0.020
Absorbance (at 310 nm) ≤ 0.010
The spectrum shows a steadily descending curve with no observable peaks or shoulders conforms
Peroxides conforms
Volatile Impurities (GC) (individual) ≤ 0.1 % (v/v)
Volatile Impurities (GC) (total) ≤ 1.0 % (v/v)
Benzene and related substances (GC) (Benzene) ≤ 2 ppm
Benzene and related substances (GC) (total of impurities apart from 2-butanol) ≤ 0.3 %
Cyclohexane (GC) ≤ 50 ppm
Acetone (GC) ≤ 50 ppm
Ethanol (GC) ≤ 50 ppm
1-Propylalcohol (GC) ≤ 50 ppm
Isopropylether (GC) ≤ 0.01 %
Other residual solvents (ICH Q3C) excluded by manufacturing process
Evaporation residue ≤ 0.0020 %
Water ≤ 0.20 %
Residues of metal catalysts or metal reagents acc. to EMEA/CHMP/SWP/4446/2000 are not likely to be present.
Conforms to Ph Eur, BP, JP, USP

2-Propanol

M100995.2500

1.00995.2500

1009952500

Laboratuvar Kimyasalları

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